Home Medical Science SARS-CoV-2 can infect the placenta and is not associated with specific placental histopathology: a series of 19 placentas from COVID-19-positive mothers

SARS-CoV-2 can infect the placenta and is not associated with specific placental histopathology: a series of 19 placentas from COVID-19-positive mothers

by World Health Now
0 comment


  • 1.

    Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382:727–33.

    CAS 
    Article 

    Google Scholar 

  • 2.

    Hoffmann M, Kleine-Weber H, Schroeder S, Kruger N, Herrler T, Erichsen S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020;181:e8.

    Article 

    Google Scholar 

  • 3.

    Mullins E, Evans D, Viner RM, O’Brien P, Morris E. Coronavirus in pregnancy and delivery: rapid review. Ultrasound Obstet Gynecol. 2020;55:586–92.

    CAS 
    Article 

    Google Scholar 

  • 4.

    Baud D, Greub G, Favre G, Gengler C, Jaton K, Dubruc E, et al. Second-trimester miscarriage in a pregnant woman with SARS-CoV-2 infection. JAMA. 2020. https://doi.org/10.1001/jama.2020.7233.

  • 5.

    Kirtsman M, Diambomba Y, Poutanen SM, Malinowski AK, Vlachodimitropoulou E, Parks WT, et al. Probable congenital SARS-CoV-2 infection in a neonate born to a woman with active SARS-CoV-2 infection. CMAJ. 2020;192:E647–50.

    CAS 
    Article 

    Google Scholar 

  • 6.

    Chen S, Huang B, Luo DJ, Li X, Yang F, Zhao Y, et al. [Pregnant women with new coronavirus infection: a clinical characteristics and placental pathological analysis of three cases]. Zhonghua Bing Li Xue Za Zhi. 2020;49:E005.

    Google Scholar 

  • 7.

    Liu Y, Chen H, Tang K, Guo Y. Clinical manifestations and outcome of SARS-CoV-2 infection during pregnancy. J Infect. 2020. https://doi.org/10.1016/j.inf.2020.02.028.

  • 8.

    Zhu H, Wang L, Fang C, Peng S, Zhang L, Chang G, et al. Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia. Transl Pediatr. 2020;9:51–60.

    Article 

    Google Scholar 

  • 9.

    Hosier H, Farhadian R, Morotti R, Deshmukh U, Lu-Culligan A, Campbell K, et al. SARS-CoV-2 infection of the placenta. 2020. https://doi.org/10.1172/JCI139569.

  • 10.

    Patane L, Morotti D, Giunta MR, Sigismondi C, Piccoli MG, Frigerio L, et al. Vertical transmissioin of coronavirus disease 2019: severe acute respiratory syndrome coronavirus 2 RNA on the fetal side of the placenta in pregnancies with COVID-19-positive mothers and neonates at birth. AJOG MFM. 2020. https://doi.org/10.1016/j.ajogmf.2020.100145.

  • 11.

    Redline RW, Boyd TK, Roberts DJ, editors. Placental and gestational pathology. Vol 1. Cambridge, UK: Cambridge University Place; 2018. p. 344.

  • 12.

    Parry S, Holder J, Strauss JF 3rd. Mechanisms of trophoblast-virus interaction. J Reprod Immunol. 1997;37:25–34.

    CAS 
    Article 

    Google Scholar 

  • 13.

    Koi H, Zhang J, Parry S. The mechanisms of placental viral infection. Ann N Y Acad Sci. 2001;943:148–56.

    CAS 
    Article 

    Google Scholar 

  • 14.

    Baergen RN, Heller DS. Placental pathology in Covid-19 positive mothers: preliminary findings. Pediatr Dev Pathol. 2020;23:177–80.

    Article 

    Google Scholar 

  • 15.

    Shuo C, Bo H, Danju L, Xiang L, Fan Y, Yin Z, et al. Clinical characteristics and pathological analysis of placenta in three cases of pregnant women with novel coronavirus infection. Chin J Pathol. 2020;49:418–23.

    Google Scholar 

  • 16.

    Shanes ED, Mithal LB, Otero S, Azad HA, Miller ES, Goldstein JA. Placental pathology in COVID-19. Am J Clin Pathol. 2020;154:23–32.

    CAS 
    Article 

    Google Scholar 

  • 17.

    Massoth LR, Desai N, Szabolcs A, Harris CK, Neyaz A, Crotty R, et al. Comparison of RNA in-situ hybridization and immunohistochmistry techniques for the detection and localization of SARS-CoV-2 in human tissues. Am J Surg Pathol. 2020. In press.

  • 18.

    Khong TY, Mooney EE, Ariel I, Balmus NC, Boyd TK, Brundler MA, et al. Sampling and definitions of placental lesions: Amsterdam Placental Workshop Group Consensus Statement. Arch Pathol Lab Med. 2016;140:698–713.

    Article 

    Google Scholar 

  • 19.

    Alamar I, Heyman T, Abu-Arja M, Zhang P, Salafia CM, Roberts DJ, et al. A SARS-COV-2 positive triad: mother, placenta and newborn. J Ped Infect Dis Soc. Under review.

  • 20.

    Ebbing C, Kiserud T, Johnsen SL, Albrechtsen S, Rasmussen S. Prevalence, risk factors and outcomes of velamentous and marginal cord insertions: a population-based study of 634,741 pregnancies. PLoS ONE. 2013;8:e70380.

    CAS 
    Article 

    Google Scholar 

  • 21.

    Catov JM, Muldoon MF, Reis SE, Ness RB, Nguyen LN, Yamal JM, et al. Preterm birth with placental evidence of malperfusion is associated with cardiovascular risk factors after pregnancy: a prospective cohort study. BJOG. 2017;125:1009–17.

    Article 

    Google Scholar 

  • 22.

    Faye-Petersen OM, Ernst LM. Maternal floor infarction and massive perivillous fibrin deposition. Surg Pathol Clin. 2013;6:101–14.

    Article 

    Google Scholar 

  • 23.

    Vik T, Redline R, Nelson KB, Bjellmo S, Vogt C, Ng P, et al. The placenta in neonatal encephalopathy: a case-control study. J Pediatr. 2018;202:e3.

    Article 

    Google Scholar 

  • 24.

    Bos M, Nikkels PGJ, Cohen D, Schoones JW, Bloemenkamp KWM, Bruijn JA, et al. Towards standardized criteria for diagnosing chronic intervillositis of unknown etiology: a systematic review. Placenta. 2018;61:80–8.

    CAS 
    Article 

    Google Scholar 

  • 25.

    Redline RW. Villitis of unknown etiology: noninfectious chronic villitis in the placenta. Hum Pathol. 2007;38:1439–46.

    Article 

    Google Scholar 

  • 26.

    Yu N, Li W, Kang Q, Xiong Z, Wang S, Lin X, et al. Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study. Lancet Infect Dis. 2020;20:559–64.

    CAS 
    Article 

    Google Scholar 

  • 27.

    Yan J, Guo J, Fan C, Juan J, Yu X, Li J, et al. Coronavirus disease 2019 (COVID-19) in pregnant women: a report based on 116 cases. Am J Obstet Gynecol. 2020;223:111e1–14.

  • 28.

    Schwartz DA, Dhaliwal A. Infections in pregnancy with covid-19 and other respiratory rna virus diseases are rarely, if ever, transmitted to the fetus: experiences with Coronaviruses, HPIV, hMPV, RSV, and Influenza A. Arch Pathol Lab Med. 2020. https://doi.org/10.5858/arpa.2020-0211-SA.

  • 29.

    Liu D, Li L, Wu X, Zheng D, Wang J, Yang L, et al. Pregnancy and perinatal outcomes of women with coronavirus disease (COVID-19) pneumonia: a preliminary analysis. Am J Roentgenol. 2020;215:1–6.

  • 30.

    Dong L, Tian J, He S, Zhu C, Wang J, Liu C, et al. Possible vertical transmission of SARS-CoV-2 from an infected mother to her newborn. JAMA. 2020. https://doi.org/10.1001/jama.2020.4621.

  • 31.

    Zeng H, Xu C, Fan J, Tang Y, Deng Q, Zhang W, et al. Antibodies in infants born to mothers with COVID-19 pneumonia. JAMA. 2020. https://doi.org/10.1001/jama.2020.4861.

  • 32.

    Pinar H, Sung CJ, Oyer CE, Singer DB. Reference values for singleton and twin placental weights. Pediatr Pathol Lab Med. 1996;16:901–7.

    CAS 
    Article 

    Google Scholar 



  • Source link

    You may also like

    Leave a Comment